Genotoxic thresholds, DNA repair, and susceptibility in human populations
نویسندگان
چکیده
منابع مشابه
Genotoxic thresholds, DNA repair, and susceptibility in human populations.
It has been long assumed that DNA damage is induced in a linear manner with respect to the dose of a direct acting genotoxin. Thus, it is implied that direct acting genotoxic agents induce DNA damage at even the lowest of concentrations and that no "safe" dose range exists. The linear (non-threshold) paradigm has led to the one-hit model being developed. This "one hit" scenario can be interpret...
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ژورنال
عنوان ژورنال: Toxicology
سال: 2010
ISSN: 0300-483X
DOI: 10.1016/j.tox.2009.11.016